NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway

NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of...

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Published in:Oncotarget 2015-09, Vol.6 (28), p.25701-25714
Main Authors: Lei, Jin-Ju, Peng, Rou-Jun, Kuang, Bo-Hua, Yuan, Zhong-Yu, Qin, Tao, Liu, Wen-Sheng, Guo, Yun-Miao, Han, Hui-Qiong, Lian, Yi-Fan, Deng, Cheng-Cheng, Zhang, Hao-Jiong, Chen, Li-Zhen, Feng, Qi-Sheng, Xu, Miao, Feng, Lin, Bei, Jin-Xin, Zeng, Yi-Xin
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Adult
Animals
beta Catenin - metabolism
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Cell Movement
Cell Proliferation
Disease-Free Survival
Estrogen Receptor alpha - metabolism
Female
Gene Expression Regulation, Neoplastic
Humans
Kaplan-Meier Estimate
MCF-7 Cells
Mice, Nude
Neoplasm Invasiveness
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Research Paper
RNA Interference
Time Factors
Transfection
Tumor Burden
Wnt Signaling Pathway
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Summary:NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERα expression and inhibited the Wnt/β-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival (P = 0.0006) and disease-free survival (P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.4573