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The neurosteroidogenic enzyme 5α-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating

Highlights • We tested finasteride on the PPI deficits induced by selective DA receptor agonists in rats. • In Long–Evans, finasteride opposed the PPI deficits induced by D1 , but not D2 receptors. • In Sprague–Dawley, finasteride prevented the PPI loss and accumbal DA levels caused by D3, but not D...

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Published in:Psychoneuroendocrinology 2016-01, Vol.63, p.59-67
Main Authors: Frau, Roberto, Mosher, Laura J, Bini, Valentina, Pillolla, Giuliano, Pes, Romina, Saba, Pierluigi, Fanni, Silvia, Devoto, Paola, Bortolato, Marco
Format: Article
Language:English
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Summary:Highlights • We tested finasteride on the PPI deficits induced by selective DA receptor agonists in rats. • In Long–Evans, finasteride opposed the PPI deficits induced by D1 , but not D2 receptors. • In Sprague–Dawley, finasteride prevented the PPI loss and accumbal DA levels caused by D3, but not D2 receptors.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.09.014