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The neurosteroidogenic enzyme 5α-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating
Highlights • We tested finasteride on the PPI deficits induced by selective DA receptor agonists in rats. • In Long–Evans, finasteride opposed the PPI deficits induced by D1 , but not D2 receptors. • In Sprague–Dawley, finasteride prevented the PPI loss and accumbal DA levels caused by D3, but not D...
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Published in: | Psychoneuroendocrinology 2016-01, Vol.63, p.59-67 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights • We tested finasteride on the PPI deficits induced by selective DA receptor agonists in rats. • In Long–Evans, finasteride opposed the PPI deficits induced by D1 , but not D2 receptors. • In Sprague–Dawley, finasteride prevented the PPI loss and accumbal DA levels caused by D3, but not D2 receptors. |
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ISSN: | 0306-4530 1873-3360 |
DOI: | 10.1016/j.psyneuen.2015.09.014 |