Patient-Specific Therapy via Cell-Reprogramming Technology: a Curative Potential for Patients with Diabetes

Gene therapeutics provides great opportunities for curing diabetes. Numerous attempts have been made to establish a safe and high-efficiency gene delivery strategy, but all of them are unsuccessful. To achieve an ideal transfection, a novel gene delivery strategy was presented in this research. The...

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Bibliographic Details
Published in:Nanoscale research letters 2015-12, Vol.10 (1), p.496-496, Article 496
Main Authors: Luo, Haizhao, Wang, Xianbao, Zhang, Ruyi, Chen, Youping, Shu, Yi, Li, Huixian, Chen, Hong
Format: Article
Language:English
Subjects:
Chemistry and Materials Science
Crosslinking
Diabetes
Endosomes
Genes
Materials Science
Molecular Medicine
Nano Idea
Nanochemistry
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
Patients
Polyetherimides
Strategy
Ultrasound
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Summary:Gene therapeutics provides great opportunities for curing diabetes. Numerous attempts have been made to establish a safe and high-efficiency gene delivery strategy, but all of them are unsuccessful. To achieve an ideal transfection, a novel gene delivery strategy was presented in this research. The novel system proposed was transfection mediated by the combination of ultrasound with microbubbles and cross-linked polyethylenimines (PEIs). Ultrasound with microbubbles enhances the permeability of target cells; moreover, cross-linked PEIs enabled DNA to escape from endosomes into the cytoplasm. If the proposed method is feasible and effective, the endogenous secretion system of insulin would be re-established in patients with diabetes.
ISSN:1931-7573
1556-276X
DOI:10.1186/s11671-015-1193-8