Catalpol induces oligodendrocyte precursor cell-mediated remyelination in vitro

In demyelinating diseases such as multiple sclerosis, one of the treatment strategies includes remyelination using oligodendrocyte precursor cells (OPC). Catalpol, the extract of radix rehmanniae, is neuroprotective. Using an OPC culture model, we showed that 10 μM catalpol promotes OPC proliferatio...

Full description

Saved in:
Bibliographic Details
Published in:American journal of translational research 2015-01, Vol.7 (11), p.2474-2481
Main Authors: Yuan, Chun-Xiao, Chu, Takho, Liu, Li, Li, Hao-Wen, Wang, Ya-Jie, Guo, An-Chen, Fan, Yong-Ping
Format: Article
Language:English
Subjects:
Original
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In demyelinating diseases such as multiple sclerosis, one of the treatment strategies includes remyelination using oligodendrocyte precursor cells (OPC). Catalpol, the extract of radix rehmanniae, is neuroprotective. Using an OPC culture model, we showed that 10 μM catalpol promotes OPC proliferation, cell migration and differentiation into mature oligodendrocytes. The 10 μM catalpol displayed stronger effects on OPCs migration and oligodendrocyte differentiation. These results suggest that catalpol has a potential role in promoting remyelination in demyelinating diseases, and is of therapeutic interest.
ISSN:1943-8141
1943-8141