Activation of Antioxidative Functions by Radon Inhalation Enhances the Mitigation Effects of Pregabalin on Chronic Constriction Injury-Induced Neuropathic Pain in Mice

Radon inhalation brings pain relief for chronic constriction injury- (CCI-) induced neuropathic pain in mice due to the activation of antioxidative functions, which is different from the mechanism of the pregabalin effect. In this study, we assessed whether a combination of radon inhalation and preg...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-8
Main Authors: Yamaoka, Kiyonori, Kobashi, Yusuke, Sasaoka, Kaori, Kanzaki, Norie, Etani, Reo, Horie, Shunsuke, Kataoka, Takahiro, Hanamoto, Katsumi
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Antioxidants - pharmacology
Antioxidants - therapeutic use
Cancer therapies
Care and treatment
Constriction
Drug dosages
Gases, Rare
Health aspects
Male
Mice, Inbred ICR
Neuralgia - drug therapy
Neuralgia - pathology
Pain
Pregabalin
Pregabalin - administration & dosage
Pregabalin - therapeutic use
Radon
Radon - administration & dosage
Radon - therapeutic use
Rheumatic diseases
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Summary:Radon inhalation brings pain relief for chronic constriction injury- (CCI-) induced neuropathic pain in mice due to the activation of antioxidative functions, which is different from the mechanism of the pregabalin effect. In this study, we assessed whether a combination of radon inhalation and pregabalin administration is more effective against neuropathic pain than radon or pregabalin only. Mice were treated with inhaled radon at a concentration of 1,000 Bq/m3 for 24 hours and pregabalin administration after CCI surgery. In mice treated with pregabalin at a dose of 3 mg/kg weight, the 50% paw withdrawal threshold of mice treated with pregabalin or radon and pregabalin was significantly increased, suggesting pain relief. The therapeutic effects of radon inhalation or the combined effects of radon and pregabalin (3 mg/kg weight) were almost equivalent to treatment with pregabalin at a dose of 1.4 mg/kg weight or 4.1 mg/kg weight, respectively. Radon inhalation and the combination of radon and pregabalin increased antioxidant associated substances in the paw. The antioxidant substances increased much more in radon inhalation than in pregabalin administration. These findings suggested that the activation of antioxidative functions by radon inhalation enhances the pain relief of pregabalin and that this combined effect is probably an additive effect.
ISSN:1942-0900
1942-0994
DOI:10.1155/2016/9853692