Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs

• Published in: Obesity (Silver Spring, Md.) Md.), 2015-12, Vol.23 (12), p.2421-2429
• Main Authors: Vieira‐Potter, Victoria J., Lee, Sewon, Bayless, David S., Scroggins, Rebecca J., Welly, Rebecca J., Fleming, Nicholas J., Smith, Thomas N., Meers, Grace M., Hill, Michael A., Rector, R. Scott, Padilla, Jaume
• Format: Article
• Language: English
• Subjects: Adipocytes; Adipose Tissue - metabolism; Animals; Atherosclerosis; Biomarkers - metabolism; Blood pressure; Body composition; Body fat; Cardiovascular disease; Coronary Artery Disease - etiology; Coronary vessels; Diet; Diet, Fat-Restricted; Diet, High-Fat - adverse effects; Disease Models, Animal; Dyslipidemias - etiology; Female; Females; Hogs; Hypertension - etiology; Inflammation; Insulin - metabolism; Insulin Resistance; Metabolism; Mortality; Obesity; Obesity - etiology; Obesity - genetics; Obesity - physiopathology; Panniculitis - etiology; Panniculitis - physiopathology; Phenotype; Random Allocation; Rodents; Studies; Swine; Tumor necrosis factor-TNF; Weight control
• ISSN: 1930-7381; 1930-739X
• DOI: 10.1002/oby.21252

Objective The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease because of its size and susceptibility to atherosclerosis, among other characteristics. The relationship between adipose tissue inflammation and metabolic dysfunction in this model was investigated here. Methods Young female Ossabaw pigs were fed a Western‐style high‐fat diet (HFD) (n = 4) or control low‐fat diet (LFD) (n = 4) for a period of 9 months and compared for cardiometabolic outcomes and adipose tissue inflammation. Results The HFD‐fed “OBESE” pigs were 2.5 times heavier (P