Association between Serum Potassium and Outcomes in Patients with Reduced Kidney Function

Patients with CKD are more likely than others to have abnormalities in serum potassium (K(+)). Aside from severe hyperkalemia, the clinical significance of K(+) abnormalities is not known. We sought to examine the association of serum K(+) with mortality and hospitalization rates within narrow eGFR...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2016-01, Vol.11 (1), p.90-100
Main Authors: Luo, Jiacong, Brunelli, Steven M, Jensen, Donna E, Yang, Alex
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Angiotensin Receptor Antagonists - therapeutic use
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Cardiovascular Diseases - epidemiology
Female
Glomerular Filtration Rate
Hospitalization
Humans
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - drug therapy
Kidney Failure, Chronic - mortality
Kidney Failure, Chronic - physiopathology
Male
Middle Aged
Original
Potassium - blood
Retrospective Studies
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Summary:Patients with CKD are more likely than others to have abnormalities in serum potassium (K(+)). Aside from severe hyperkalemia, the clinical significance of K(+) abnormalities is not known. We sought to examine the association of serum K(+) with mortality and hospitalization rates within narrow eGFR strata to understand how the burden of hyperkalemia varies by CKD severity. Associations were examined between serum K(+) and discontinuation of medications that block the renin-angiotensin-aldosterone system (RAAS), which are known to increase serum K(+). A cohort of patients with CKD (eGFR
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.01730215