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Azole Resistance in Aspergillus fumigatus Clinical Isolates from an Italian Culture Collection
The aims of the study were to investigate the prevalence of azole resistance among Aspergillus fumigatus clinical isolates. A total of 533 clinical isolates that had been collected between 1995 and 2006, from 441 patients, were screened. No resistance was detected in isolates collected between 1995...
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| Published in: | Antimicrobial agents and chemotherapy 2016-01, Vol.60 (1), p.682-685 |
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| cited_by | cdi_FETCH-LOGICAL-a517t-c381dd548d2b779ae215327b900526343849ac019e62e1d7f403522fb29bdb4a3 |
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| cites | cdi_FETCH-LOGICAL-a517t-c381dd548d2b779ae215327b900526343849ac019e62e1d7f403522fb29bdb4a3 |
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| container_title | Antimicrobial agents and chemotherapy |
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| creator | Lazzarini, Cristina Esposto, Maria Carmela Prigitano, Anna Cogliati, Massimo De Lorenzis, Gabriella Tortorano, Anna Maria |
| description | The aims of the study were to investigate the prevalence of azole resistance among Aspergillus fumigatus clinical isolates. A total of 533 clinical isolates that had been collected between 1995 and 2006, from 441 patients, were screened. No resistance was detected in isolates collected between 1995 and 1997. Starting in 1998, the resistance rate was 6.9%; a total of 24 patients (6.25%) harbored a resistant isolate. The TR34/L98H substitution was found in 21 of 30 tested isolates. |
| doi_str_mv | 10.1128/AAC.02234-15 |
| format | article |
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A total of 533 clinical isolates that had been collected between 1995 and 2006, from 441 patients, were screened. No resistance was detected in isolates collected between 1995 and 1997. Starting in 1998, the resistance rate was 6.9%; a total of 24 patients (6.25%) harbored a resistant isolate. The TR34/L98H substitution was found in 21 of 30 tested isolates.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.02234-15</identifier><identifier>PMID: 26552980</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Amino Acid Substitution ; Antifungal Agents ; Antifungal Agents - pharmacology ; Aspergillosis ; Aspergillosis - drug therapy ; Aspergillosis - epidemiology ; Aspergillosis - microbiology ; Aspergillus fumigatus ; Aspergillus fumigatus - drug effects ; Aspergillus fumigatus - enzymology ; Aspergillus fumigatus - genetics ; Aspergillus fumigatus - isolation & purification ; Bacterial Typing Techniques ; Cytochrome P-450 Enzyme System ; Cytochrome P-450 Enzyme System - genetics ; Cytochrome P-450 Enzyme System - metabolism ; Drug Resistance, Fungal ; Drug Resistance, Fungal - genetics ; Epidemiological Monitoring ; Fungal Proteins ; Fungal Proteins - genetics ; Fungal Proteins - metabolism ; Gene Expression ; Genotype ; Humans ; Italy - epidemiology ; Itraconazole - pharmacology ; Microbial Sensitivity Tests ; Microsatellite Repeats ; Mutation ; Promoter Regions, Genetic ; Susceptibility ; Triazoles - pharmacology ; Voriconazole - pharmacology</subject><ispartof>Antimicrobial agents and chemotherapy, 2016-01, Vol.60 (1), p.682-685</ispartof><rights>Copyright © 2015, American Society for Microbiology. All Rights Reserved.</rights><rights>Copyright © 2015, American Society for Microbiology. All Rights Reserved. 2015 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a517t-c381dd548d2b779ae215327b900526343849ac019e62e1d7f403522fb29bdb4a3</citedby><cites>FETCH-LOGICAL-a517t-c381dd548d2b779ae215327b900526343849ac019e62e1d7f403522fb29bdb4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.asm.org/doi/pdf/10.1128/AAC.02234-15$$EPDF$$P50$$Gasm2$$H</linktopdf><linktohtml>$$Uhttps://journals.asm.org/doi/full/10.1128/AAC.02234-15$$EHTML$$P50$$Gasm2$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,3187,27923,27924,52750,52751,52752,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26552980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lazzarini, Cristina</creatorcontrib><creatorcontrib>Esposto, Maria Carmela</creatorcontrib><creatorcontrib>Prigitano, Anna</creatorcontrib><creatorcontrib>Cogliati, Massimo</creatorcontrib><creatorcontrib>De Lorenzis, Gabriella</creatorcontrib><creatorcontrib>Tortorano, Anna Maria</creatorcontrib><title>Azole Resistance in Aspergillus fumigatus Clinical Isolates from an Italian Culture Collection</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>The aims of the study were to investigate the prevalence of azole resistance among Aspergillus fumigatus clinical isolates. 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The TR34/L98H substitution was found in 21 of 30 tested isolates.</description><subject>Amino Acid Substitution</subject><subject>Antifungal Agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>Aspergillosis</subject><subject>Aspergillosis - drug therapy</subject><subject>Aspergillosis - epidemiology</subject><subject>Aspergillosis - microbiology</subject><subject>Aspergillus fumigatus</subject><subject>Aspergillus fumigatus - drug effects</subject><subject>Aspergillus fumigatus - enzymology</subject><subject>Aspergillus fumigatus - genetics</subject><subject>Aspergillus fumigatus - isolation & purification</subject><subject>Bacterial Typing Techniques</subject><subject>Cytochrome P-450 Enzyme System</subject><subject>Cytochrome P-450 Enzyme System - genetics</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Drug Resistance, Fungal</subject><subject>Drug Resistance, Fungal - genetics</subject><subject>Epidemiological Monitoring</subject><subject>Fungal Proteins</subject><subject>Fungal Proteins - genetics</subject><subject>Fungal Proteins - metabolism</subject><subject>Gene Expression</subject><subject>Genotype</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Itraconazole - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Microsatellite Repeats</subject><subject>Mutation</subject><subject>Promoter Regions, Genetic</subject><subject>Susceptibility</subject><subject>Triazoles - pharmacology</subject><subject>Voriconazole - pharmacology</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1UU1r3DAUFCGl2Wx7y7n4mECdSLJkS5eCMWmysFAI7bVCtp-3CrK0leRA8uvr7CZLc8hp3mOGeR-D0BnBl4RQcVXXzSWmtGA54UdoQbAUeclleYwWGJdlzgRmJ-g0xns891zij-iElpxTKfAC_a6fvIXsDqKJSbsOMuOyOm4hbIy1U8yGaTQbneaqscaZTttsFb3VCWYu-DHTLlslbc2MzWTTFCBrvLXQJePdJ_Rh0DbC5xdcol_fr382t_n6x82qqde55qRKeVcI0veciZ62VSU1UMILWrUSY07LghWCSd1hIqGkQPpqYLjglA4tlW3fMl0s0be973ZqR-g7cCloq7bBjDo8Kq-Ness480dt_INiFWYUk9ng_MUg-L8TxKRGEzuwVjvwU1Sk4oIy8bzXEn3dS7vgYwwwHMYQrJ4jUXMkaheJ2skv9nIdR6ru_RTc_In3tF_-P-Ng_JpX8Q-8-ZQW</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Lazzarini, Cristina</creator><creator>Esposto, Maria Carmela</creator><creator>Prigitano, Anna</creator><creator>Cogliati, Massimo</creator><creator>De Lorenzis, Gabriella</creator><creator>Tortorano, Anna Maria</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Azole Resistance in Aspergillus fumigatus Clinical Isolates from an Italian Culture Collection</title><author>Lazzarini, Cristina ; Esposto, Maria Carmela ; Prigitano, Anna ; Cogliati, Massimo ; De Lorenzis, Gabriella ; Tortorano, Anna Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a517t-c381dd548d2b779ae215327b900526343849ac019e62e1d7f403522fb29bdb4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Amino Acid Substitution</topic><topic>Antifungal Agents</topic><topic>Antifungal Agents - pharmacology</topic><topic>Aspergillosis</topic><topic>Aspergillosis - drug therapy</topic><topic>Aspergillosis - epidemiology</topic><topic>Aspergillosis - microbiology</topic><topic>Aspergillus fumigatus</topic><topic>Aspergillus fumigatus - drug effects</topic><topic>Aspergillus fumigatus - enzymology</topic><topic>Aspergillus fumigatus - genetics</topic><topic>Aspergillus fumigatus - isolation & purification</topic><topic>Bacterial Typing Techniques</topic><topic>Cytochrome P-450 Enzyme System</topic><topic>Cytochrome P-450 Enzyme System - genetics</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Drug Resistance, Fungal</topic><topic>Drug Resistance, Fungal - genetics</topic><topic>Epidemiological Monitoring</topic><topic>Fungal Proteins</topic><topic>Fungal Proteins - genetics</topic><topic>Fungal Proteins - metabolism</topic><topic>Gene Expression</topic><topic>Genotype</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Itraconazole - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Microsatellite Repeats</topic><topic>Mutation</topic><topic>Promoter Regions, Genetic</topic><topic>Susceptibility</topic><topic>Triazoles - pharmacology</topic><topic>Voriconazole - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lazzarini, Cristina</creatorcontrib><creatorcontrib>Esposto, Maria Carmela</creatorcontrib><creatorcontrib>Prigitano, Anna</creatorcontrib><creatorcontrib>Cogliati, Massimo</creatorcontrib><creatorcontrib>De Lorenzis, Gabriella</creatorcontrib><creatorcontrib>Tortorano, Anna Maria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lazzarini, Cristina</au><au>Esposto, Maria Carmela</au><au>Prigitano, Anna</au><au>Cogliati, Massimo</au><au>De Lorenzis, Gabriella</au><au>Tortorano, Anna Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Azole Resistance in Aspergillus fumigatus Clinical Isolates from an Italian Culture Collection</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>60</volume><issue>1</issue><spage>682</spage><epage>685</epage><pages>682-685</pages><issn>0066-4804</issn><eissn>1098-6596</eissn><abstract>The aims of the study were to investigate the prevalence of azole resistance among Aspergillus fumigatus clinical isolates. 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| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial agents and chemotherapy, 2016-01, Vol.60 (1), p.682-685 |
| issn | 0066-4804 1098-6596 |
| language | eng |
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| source | American Society for Microbiology Journals; PubMed Central |
| subjects | Amino Acid Substitution Antifungal Agents Antifungal Agents - pharmacology Aspergillosis Aspergillosis - drug therapy Aspergillosis - epidemiology Aspergillosis - microbiology Aspergillus fumigatus Aspergillus fumigatus - drug effects Aspergillus fumigatus - enzymology Aspergillus fumigatus - genetics Aspergillus fumigatus - isolation & purification Bacterial Typing Techniques Cytochrome P-450 Enzyme System Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Drug Resistance, Fungal Drug Resistance, Fungal - genetics Epidemiological Monitoring Fungal Proteins Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Genotype Humans Italy - epidemiology Itraconazole - pharmacology Microbial Sensitivity Tests Microsatellite Repeats Mutation Promoter Regions, Genetic Susceptibility Triazoles - pharmacology Voriconazole - pharmacology |
| title | Azole Resistance in Aspergillus fumigatus Clinical Isolates from an Italian Culture Collection |
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