Reading salt activates gustatory brain regions: fMRI evidence for semantic grounding in a novel sensory modality

• Published in: Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2012-11, Vol.22 (11), p.2554-2563
• Main Authors: Barrós-Loscertales, Alfonso, González, Julio, Pulvermüller, Friedemann, Ventura-Campos, Noelia, Bustamante, Juan Carlos, Costumero, Víctor, Parcet, María Antonia, Ávila, César
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Analysis of Variance; Cerebral Cortex - physiology; Data Interpretation, Statistical; Female; Frontal Lobe - physiology; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Reading; Sodium Chloride, Dietary; Somatosensory Cortex - physiology; Taste - physiology; Thalamus - physiology; Young Adult
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhr324

Because many words are typically used in the context of their referent objects and actions, distributed cortical circuits for these words may bind information about their form with perceptual and motor aspects of their meaning. Previous work has demonstrated such semantic grounding for sensorimotor, visual, auditory, and olfactory knowledge linked to words, which is manifest in activation of the corresponding areas of the cortex. Here, we explore the brain basis of gustatory semantic links of words whose meaning is primarily related to taste. In a blocked functional magnetic resonance imaging design, Spanish taste words and control words matched for a range of factors (including valence, arousal, image-ability, frequency of use, number of letters and syllables) were presented to 59 right-handed participants in a passive reading task. Whereas all the words activated the left inferior frontal (BA44/45) and the posterior middle and superior temporal gyri (BA21/22), taste-related words produced a significantly stronger activation in these same areas and also in the anterior insula, frontal operculum, lateral orbitofrontal gyrus, and thalamus among others. As these areas comprise primary and secondary gustatory cortices, we conclude that the meaning of taste words is grounded in distributed cortical circuits reaching into areas that process taste sensations.