Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials

We aimed to assess the impact of L-carnitine on plasma Lp(a) concentrations through systematic review and meta-analysis of available RCTs. The literature search included selected databases up to 31 st January 2015. Meta-analysis was performed using fixed-effects or random-effect model according to I...

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Bibliographic Details
Published in:Scientific reports 2016-01, Vol.6 (1), p.19188-19188, Article 19188
Main Authors: Serban, Maria-Corina, Sahebkar, Amirhossein, Mikhailidis, Dimitri P., Toth, Peter P., Jones, Steven R., Muntner, Paul, Blaha, Michael J., Andrica, Florina, Martin, Seth S., Borza, Claudia, Lip, Gregory Y. H., Ray, Kausik K., Rysz, Jacek, Hazen, Stanley L., Banach, Maciej
Format: Article
Language:English
Subjects:
692/4019/592/75/2099
692/499
Carnitine
Carnitine - blood
Clinical trials
Dietary Supplements
Humanities and Social Sciences
Humans
Intravenous administration
Lipids - blood
Lipoprotein(a) - blood
Meta-analysis
multidisciplinary
Oxidation
Population Surveillance
Publication Bias
Randomized Controlled Trials as Topic
Regression analysis
Science
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Summary:We aimed to assess the impact of L-carnitine on plasma Lp(a) concentrations through systematic review and meta-analysis of available RCTs. The literature search included selected databases up to 31 st January 2015. Meta-analysis was performed using fixed-effects or random-effect model according to I 2 statistic. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence interval (CI). The meta-analysis showed a significant reduction of Lp(a) levels following L-carnitine supplementation (WMD: −8.82 mg/dL, 95% CI: −10.09, −7.55, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/srep19188