Galanin regulates blood glucose level in the zebrafish: a morphological and functional study

The present study has demonstrated the galaninergic innervation of the endocrine pancreas including sources of the galaninergic nerve fibers, and the influence of galanin receptor agonists on blood glucose level in the zebrafish. For the first time, a very abundant galaninergic innervation of the en...

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Bibliographic Details
Published in:Histochemistry and cell biology 2016-01, Vol.145 (1), p.105-117
Main Authors: Podlasz, P., Jakimiuk, A., Chmielewska-Krzesinska, M., Kasica, N., Nowik, N., Kaleczyc, J.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Blood Glucose - analysis
Blood Glucose - drug effects
Cell Biology
Cellular biology
Developmental Biology
Female
Galanin - analogs & derivatives
Galanin - pharmacology
Ganglia, Parasympathetic - metabolism
Glucose
Insulin
Islets of Langerhans - metabolism
Lipopeptides - pharmacology
Male
Morphology
Original Paper
Receptors, Galanin - agonists
Zebrafish
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Summary:The present study has demonstrated the galaninergic innervation of the endocrine pancreas including sources of the galaninergic nerve fibers, and the influence of galanin receptor agonists on blood glucose level in the zebrafish. For the first time, a very abundant galaninergic innervation of the endocrine pancreas during development is shown, from the second day post-fertilization to adulthood. The fibers originated from ganglia consisting of galanin-IR, non-adrenergic (non-sensory) neurons located rostrally to the pancreatic tissue. The ganglia were found on the dorsal side of the initial part of the anterior intestinal segment, close to the intestinal branch of the vagus nerve. The galanin-IR neurons did not show immunoreactivity for applied antibodies against tyrosine hydroxylase, choline acetyltransferase, and vesicular acetylcholine transporter. Intraperitoneal injections of galanin analog NAX 5055 resulted in a statistically significant increase in the blood glucose level. Injections of another galanin receptor agonist, galnon, also caused a rise in blood glucose level; however, it was not statistically significant. The present findings suggest that, like in mammals, in the zebrafish galanin is involved in the regulation of blood glucose level. However, further studies are needed to elucidate the exact mechanism of the galanin action.
ISSN:0948-6143
1432-119X
DOI:10.1007/s00418-015-1376-5