Pharmacogenomics in the clinic

After decades of discovery, inherited variations have been identified in approximately 20 genes that affect about 80 medications and are actionable in the clinic. And some somatically acquired genetic variants direct the choice of 'targeted' anticancer drugs for individual patients. Curren...

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Bibliographic Details
Published in:Nature (London) 2015-10, Vol.526 (7573), p.343-350
Main Authors: Relling, Mary V., Evans, William E.
Format: Article
Language:English
Subjects:
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Cancer
Cancer therapies
Enzymes
Evidence-Based Medicine - methods
Evidence-Based Medicine - trends
Genes
Genetic Testing - trends
Genetic variance
Genetic Variation - drug effects
Genetic Variation - genetics
Genomes
Genomics
Humanities and Social Sciences
Humans
Infectious diseases
Metabolism
multidisciplinary
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - pathology
Patients
Pharmaceutical research
Pharmacogenetics
Pharmacogenetics - methods
Pharmacogenetics - trends
Pharmacology
Precision medicine
Precision Medicine - methods
Precision Medicine - trends
review-article
Science
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Summary:After decades of discovery, inherited variations have been identified in approximately 20 genes that affect about 80 medications and are actionable in the clinic. And some somatically acquired genetic variants direct the choice of 'targeted' anticancer drugs for individual patients. Current efforts that focus on the processes required to appropriately act on pharmacogenomic variability in the clinic are moving away from discovery and towards implementation of an evidenced-based strategy for improving the use of medications, thereby providing a cornerstone for precision medicine.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature15817