Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine

Highlights • CMI responses occurred following administration of an inactivated A/H5N1 vaccine. • High dose vaccine increased the magnitude of CMI response only in the unprimed subjects. • IFN-γ nSFC levels correlated with IFN-γ concentrations in PBMC supernatants.

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Bibliographic Details
Published in:Vaccine 2016-01, Vol.34 (4), p.547-554
Main Authors: Mbawuike, Innocent N, Atmar, Robert L, Patel, Shital M, Corry, David B, Winokur, Patricia L, Brady, Rebecca C, Chen, Wilbur H, Edwards, Kathryn M, Creech, C. Buddy, Walter, Emmanuel B, Frey, Sharon E, Belshe, Robert B, Goll, Johannes B, Hill, Heather, Keitel, Wendy A
Format: Article
Language:English
Subjects:
Adjuvant
Adjuvants, Immunologic - administration & dosage
Adult
Advisors
Age
Age Factors
Aged
Allergy and Immunology
Antigens
Avian flu
Cell mediated immune response
Confidence intervals
Cytokine
Cytokines
Cytokines - immunology
Female
Granzymes - immunology
H5N1
Humans
Illnesses
Immunity, Cellular
Immunization, Secondary
Immunoglobulins
Inactivated influenza vaccine
Infections
Influenza A Virus, H5N1 Subtype
Influenza Vaccines - administration & dosage
Influenza Vaccines - therapeutic use
Influenza, Human - prevention & control
Interferon-gamma - immunology
Leukocytes, Mononuclear - immunology
Male
Middle Aged
Studies
Vaccines
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - therapeutic use
Young Adult
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Description
Summary:Highlights • CMI responses occurred following administration of an inactivated A/H5N1 vaccine. • High dose vaccine increased the magnitude of CMI response only in the unprimed subjects. • IFN-γ nSFC levels correlated with IFN-γ concentrations in PBMC supernatants.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.11.055