Decreased expression of long non-coding RNA MEG3 acts as a potential predictor biomarker in progression and poor prognosis of osteosarcoma

Long non-coding RNA MEG3 (lncRNA MEG3) has been showed to involve in a variety of cancers. However, the association between lncRNA MEG3 expression level and the prognosis of osteosarcoma is still unclear. The expression levels of lncRNA MEG3 in osteosarcoma tissues and adjacent non-tumor tissues wer...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2015-01, Vol.8 (11), p.15138-15142
Main Authors: Tian, Zhi-Zhong, Guo, Xin-Jun, Zhao, Yong-Ming, Fang, Yuan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers, Tumor - genetics
Bone Neoplasms - genetics
Bone Neoplasms - metabolism
Bone Neoplasms - pathology
Child
Disease Progression
Down-Regulation
Female
Humans
Kaplan-Meier Estimate
Male
Original
Osteosarcoma - genetics
Osteosarcoma - mortality
Osteosarcoma - pathology
Prognosis
Proportional Hazards Models
Real-Time Polymerase Chain Reaction
RNA, Long Noncoding - biosynthesis
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Summary:Long non-coding RNA MEG3 (lncRNA MEG3) has been showed to involve in a variety of cancers. However, the association between lncRNA MEG3 expression level and the prognosis of osteosarcoma is still unclear. The expression levels of lncRNA MEG3 in osteosarcoma tissues and adjacent non-tumor tissues were detected using quantitative real-time PCR (qRT-PCR). Differences in patient survival were determined using the Kaplan-Meier method and a log-rank test. A Cox proportional hazards regression analysis was used for univariate and multivariate analyses of prognostic values. Our findings showed that expression of lncRNA MEG3 was clearly lower in osteosarcoma tissues compared with adjacent non-tumor tissues. The expression of lncRNA MEG3 was associated with clinical stage and distant metastasis (P
ISSN:1936-2625