Mild hyponatremia, hypernatremia and incident cardiovascular disease and mortality in older men: A population-based cohort study

Abstract Aim To examine the association between serum sodium concentration and incident major cardiovascular disease (CVD) outcomes and total mortality in older men. Methods and Results A prospective study of 3099 men aged 60–79 years without a history of cardiovascular disease followed up for an av...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2016-01, Vol.26 (1), p.12-19
Main Authors: Wannamethee, S.G, Shaper, A.G, Lennon, L, Papacosta, O, Whincup, P
Format: Article
Language:English
Subjects:
Age Factors
Aged
Biomarkers - blood
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Cause of Death
Coronary Disease - epidemiology
Humans
Hypernatremia - blood
Hypernatremia - diagnosis
Hypernatremia - epidemiology
Hypernatremia - mortality
Hyponatremia - blood
Hyponatremia - diagnosis
Hyponatremia - epidemiology
Hyponatremia - mortality
Incidence
Male
Middle Aged
Mortality
Myocardial Infarction - epidemiology
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
Serum sodium
Sex Factors
Sodium - blood
Stroke
Stroke - epidemiology
Time Factors
United Kingdom - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Aim To examine the association between serum sodium concentration and incident major cardiovascular disease (CVD) outcomes and total mortality in older men. Methods and Results A prospective study of 3099 men aged 60–79 years without a history of cardiovascular disease followed up for an average 11 years during which there were 528 major CVD events (fatal coronary heart disease [CHD] and non-fatal MI, stroke and CVD death) and 873 total deaths. A U shaped relationship was seen between serum sodium concentration and major CVD events and mortality. Hyponatremia (
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2015.07.008