Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis

Overweight and obesity are associated with breast cancer mortality. However, the relationship between postdiagnosis weight gain and mortality is unclear. We conducted a systematic review and meta-analysis of weight gain after breast cancer diagnosis and breast cancer-specific, all-cause mortality an...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2015-12, Vol.107 (12), p.djv275-djv275
Main Authors: Playdon, Mary C, Bracken, Michael B, Sanft, Tara B, Ligibel, Jennifer A, Harrigan, Maura, Irwin, Melinda L
Format: Article
Language:English
Subjects:
Adult
Aged
Body Mass Index
Breast Neoplasms - diagnosis
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cause of Death
Female
Humans
Middle Aged
Neoplasm Staging
Obesity - complications
Obesity - mortality
Odds Ratio
Overweight - complications
Overweight - mortality
Prognosis
Review
Risk Factors
Weight Gain
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Summary:Overweight and obesity are associated with breast cancer mortality. However, the relationship between postdiagnosis weight gain and mortality is unclear. We conducted a systematic review and meta-analysis of weight gain after breast cancer diagnosis and breast cancer-specific, all-cause mortality and recurrence outcomes. Electronic databases identified articles up through December 2014, including: PubMed (1966-present), EMBASE (1974-present), CINAHL (1982-present), and Web of Science. Language and publication status were unrestricted. Cohort studies and clinical trials measuring weight change after diagnosis and all-cause/breast cancer-specific mortality or recurrence were considered. Participants were women age 18 years or older with stage I-IIIC breast cancer. Fixed effects analysis summarized the association between weight gain (≥5.0% body weight) and all-cause mortality; all tests were two-sided. Twelve studies (n = 23 832) were included. Weight gain (≥5.0%) compared with maintenance (
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/djv275