A comprehensive review of the nasal microbiome in chronic rhinosinusitis (CRS)

Summary Chronic rhinosinusitis (CRS) has been known as a disease with strong infectious and inflammatory components for decades. The recent advancement in methods identifying microbes has helped implicate the airway microbiome in inflammatory respiratory diseases such as asthma and COPD. Such studie...

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Bibliographic Details
Published in:Clinical and experimental allergy 2016-01, Vol.46 (1), p.21-41
Main Authors: Mahdavinia, M., Keshavarzian, A., Tobin, M. C., Landay, A. L., Schleimer, R. P.
Format: Article
Language:English
Subjects:
Animals
Asthma - genetics
Asthma - immunology
Asthma - metabolism
Asthma - microbiology
Bacteria - classification
Bacteria - genetics
Biofilms
Chronic Disease
Disease Susceptibility
Fungi - classification
Fungi - genetics
Genetic Predisposition to Disease
Host-Pathogen Interactions
Humans
Immune system
Metagenome
Metagenomics
Microbiota
Nasal Mucosa - immunology
Nasal Mucosa - metabolism
Nasal Mucosa - microbiology
Respiratory Mucosa - immunology
Respiratory Mucosa - microbiology
Rhinitis - genetics
Rhinitis - immunology
Rhinitis - metabolism
Rhinitis - microbiology
Rhinitis - therapy
Sinusitis - genetics
Sinusitis - immunology
Sinusitis - metabolism
Sinusitis - microbiology
Sinusitis - therapy
Staphylococcus aureus - physiology
Viruses - classification
Viruses - genetics
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Summary:Summary Chronic rhinosinusitis (CRS) has been known as a disease with strong infectious and inflammatory components for decades. The recent advancement in methods identifying microbes has helped implicate the airway microbiome in inflammatory respiratory diseases such as asthma and COPD. Such studies support a role of resident microbes in both health and disease of host tissue, especially in the case of inflammatory mucosal diseases. Identifying interactive events between microbes and elements of the immune system can help us to uncover the pathogenic mechanisms underlying CRS. Here we provide a review of the findings on the complex upper respiratory microbiome in CRS in comparison with healthy controls. Furthermore, we have reviewed the defects and alterations of the host immune system that interact with microbes and could be associated with dysbiosis in CRS.
ISSN:0954-7894
1365-2222
DOI:10.1111/cea.12666