APOH interacts with FTO to predispose to healthy thinness

We identified eight candidate thinness predisposition variants from the Illumina HumanExome chip genotyped on members of pedigrees selected for either healthy thinness or severe obesity. For validation, we tested the candidates for association with healthy thinness in additional pedigree members whi...

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Bibliographic Details
Published in:Human genetics 2016-02, Vol.135 (2), p.201-207
Main Authors: Hasstedt, Sandra J., Coon, Hilary, Xin, Yuanpei, Adams, Ted D., Hunt, Steven C.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alleles
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
beta 2-Glycoprotein I - genetics
beta 2-Glycoprotein I - metabolism
Biomedical and Life Sciences
Biomedicine
Body Mass Index
Candidates
Eating disorders
Families & family life
Female
Gene Frequency
Gene Function
Genetic Predisposition to Disease
Genetics
Genomes
Genotype & phenotype
Human Genetics
Humans
Logistic Models
Male
Malnutrition
Medicine
Metabolic Diseases
Middle Aged
Molecular Medicine
Mutation, Missense
Obesity
Obesity - genetics
Original Investigation
Pedigree
Polymorphism, Single Nucleotide
Proteins - genetics
Proteins - metabolism
Quality control
Reproducibility of Results
Thinness - genetics
Young Adult
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Description
Summary:We identified eight candidate thinness predisposition variants from the Illumina HumanExome chip genotyped on members of pedigrees selected for either healthy thinness or severe obesity. For validation, we tested the candidates for association with healthy thinness in additional pedigree members while accounting for effects of obesity-associated genes: NPFFR2 , NPY2R , FTO , and MC4R. Significance was obtained for the interaction of FTO rs9939609 with APOH missense variant rs52797880 (minor allele frequency 0.054). The thinness odds ratio was estimated as 2.15 ( p  
ISSN:0340-6717
1432-1203
DOI:10.1007/s00439-015-1629-3