Adjuvant chemotherapy for resected colorectal cancer metastases: Literature review and meta-analysis

Surgical resection is the only option of cure for patients with metastatic colorectal cancer (CRC). However, the risk of recurrence within 18 mo after metastasectomy is around 75% and the liver is the most frequent site of relapse. The current international guidelines recommend an adjuvant therapy a...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2016-01, Vol.22 (2), p.519-533
Main Authors: Brandi, Giovanni, De Lorenzo, Stefania, Nannini, Margherita, Curti, Stefania, Ottone, Marta, Dall'Olio, Filippo Gustavo, Barbera, Maria Aurelia, Pantaleo, Maria Abbondanza, Biasco, Guido
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Chemotherapy, Adjuvant
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Hepatectomy - adverse effects
Hepatectomy - mortality
Hepatic Artery
Humans
Infusions, Intra-Arterial
Liver Neoplasms - mortality
Liver Neoplasms - secondary
Liver Neoplasms - therapy
Metastasectomy - adverse effects
Metastasectomy - methods
Metastasectomy - mortality
Risk Factors
Topic Highlight
Treatment Outcome
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Summary:Surgical resection is the only option of cure for patients with metastatic colorectal cancer (CRC). However, the risk of recurrence within 18 mo after metastasectomy is around 75% and the liver is the most frequent site of relapse. The current international guidelines recommend an adjuvant therapy after surgical resection of CRC metastases despite the lower level of evidence (based on the quality of studies in this setting). However, there is still no standard treatment and the effective role of an adjuvant therapy remains controversial. The aim of this review is to report the state-of-art of systemic chemotherapy and regional chemotherapy with hepatic arterial infusion in the management of patients after resection of metastases from CRC, with a literature review and meta-analysis of the relevant randomized controlled trials.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v22.i2.519