Modulation of neuronal excitability by immune mediators in epilepsy

Highlights • Inflammatory molecules have neuromodulatory effects distinct from their immune functions. • Inflammatory molecules contribute to neuronal hyperexcitability underlying seizures. • Inhibition of specific inflammatory signals reduces seizures and epileptogenesis.

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Bibliographic Details
Published in:Current opinion in pharmacology 2016-02, Vol.26, p.118-123
Main Authors: Iori, Valentina, Frigerio, Federica, Vezzani, Annamaria
Format: Article
Language:English
Subjects:
Animals
Cytokines - immunology
Epilepsy - immunology
Humans
Internal Medicine
Medical Education
Neurons - immunology
Receptors, Interleukin-1 Type I - immunology
Receptors, Tumor Necrosis Factor - immunology
Toll-Like Receptors - immunology
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Description
Summary:Highlights • Inflammatory molecules have neuromodulatory effects distinct from their immune functions. • Inflammatory molecules contribute to neuronal hyperexcitability underlying seizures. • Inhibition of specific inflammatory signals reduces seizures and epileptogenesis.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2015.11.002