Effects of Ginkgo biloba extract on cytoprotective factors in rats with duodenal ulcer

• Published in: World journal of gastroenterology : WJG 2004-02, Vol.10 (4), p.560-566
• Main Authors: Chao, Jane C J, Hung, Huei-Chen, Chen, Sheng-Hsuan, Fang, Chia-Lang
• Format: Article
• Language: English
• Subjects: Acetic Acid; Animals; Antioxidants - pharmacology; Basic Research; Cell Division - drug effects; Dinoprostone - metabolism; Duodenal Ulcer - chemically induced; Duodenal Ulcer - drug therapy; Duodenal Ulcer - pathology; Ginkgo biloba; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Male; Phytotherapy; Plant Extracts - pharmacology; Rats; Rats, Sprague-Dawley; Superoxide Dismutase - metabolism; 动物模型; 十二指肠溃疡; 细胞保护作用; 药理作用; 银杏叶提取物
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v10.i4.560

AIM:To investigate the effects of Ginkgo biloba extract on cytoprotective factors in rats with duodenal ulcer.METHODS: Sprague-Dawley rats were randomly divided into four groups: sham operation without ginkgo, sham operation with ginkgo, duodenal ulcer without ginkgo, and duodenal ulcer with ginkgo. Rats with duodenal ulcer were induced by 500mL/L acetic acid. Rats with ginkgo were intravenously injected with Ginkgo biloba extract from the tail at a dose of 0.5mg/(kg·d) for 7 and 14 days.RESULTS:Pathological result showed that duodenal ulcer rats with ginkgo improved mucosal healing and inflammation compared with those without ginkgo after 7d treatment. After 14d treatment, duodenal ulcer rats with ginkgo significantly increased weight gain (34.0±4.5g versus 24.5±9.5g,P