Cell kinetics and tumour formation. Cell turnover in the lungs of mice with hereditary lung tumours

Cell turnover time varies from one tissue to another but is reproducible as a hereditary characteristic for a given cell line. The present study indicates that it is prolonged in the lungs of mice congenitally predisposed to developing primary lung tumours. Primary malignant tumours occur more frequ...

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Bibliographic Details
Published in:Thorax 1968-01, Vol.23 (1), p.83-86
Main Authors: Divertie, M B, Shorter, R G, Titus, J L
Format: Article
Language:English
Subjects:
Animals
Cell Nucleus
DNA - biosynthesis
DNA, Neoplasm - biosynthesis
Female
Homeostasis
Lung - pathology
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Male
Mice
Mitosis
Neoplasms - etiology
Neoplasms, Experimental - genetics
Neoplasms, Experimental - pathology
Thymidine - metabolism
Tritium
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Summary:Cell turnover time varies from one tissue to another but is reproducible as a hereditary characteristic for a given cell line. The present study indicates that it is prolonged in the lungs of mice congenitally predisposed to developing primary lung tumours. Primary malignant tumours occur more frequently in areas of relatively slow cell replacement in the human gastrointestinal tract than in those where cell turnover is rapid. On the basis of these observations it is suggested that postmaturity of a cell may be a significant factor in the development of neoplastic change.
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.23.1.83