HIV-1 genetic diversity and its distribution characteristics among newly diagnosed HIV-1 individuals in Hebei province, China

• Published in: AIDS research and therapy 2016-01, Vol.13 (3), p.3-3, Article 3
• Main Authors: Lu, Xinli, Zhao, Cuiying, Wang, Wei, Nie, Chenxi, Zhang, Yuqi, Zhao, Hongru, Chen, Suliang, Cui, Ze
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; AIDS/HIV; Analysis; China - epidemiology; Cross-Sectional Studies; Female; Gene Products, env - genetics; Gene Products, gag - genetics; Genetic aspects; Genetic polymorphisms; Genetic Variation - genetics; Genotype; HIV (Viruses); HIV Infections - epidemiology; HIV Infections - genetics; HIV-1 - genetics; Humans; Male; Phylogeny; Sequence Analysis, DNA; Young Adult
• ISSN: 1742-6405; 1742-6405
• DOI: 10.1186/s12981-015-0087-2

Since the first HIV-1 case in 1989, Hebei province has presented a clearly rising trend of HIV-1 prevalence, and HIV-1 genetic diversity has become the vital barrier to HIV prevention and control in this area. To obtain detailed information of HIV-1 spread in different populations and in different areas of Hebei, a cross-sectional HIV-1 molecular epidemiological investigation was performed across the province. Blood samples of 154 newly diagnosed HIV-1 individuals were collected from ten prefectures in Hebei using stratified sampling. Partial gag and env genes were amplified and sequenced. HIV-1 genotypes were identified by phylogenetic tree analyses. Among the 139 subjects genotyped, six HIV-1 subtypes were identified successfully, including subtype B (41.0 %), CRF01_AE (40.3 %), CRF07_BC (11.5 %), CRF08_BC (4.3 %), unique recombinant forms (URFs) (1.4 %) and subtype C (1.4 %). Subtype B was identified as the most frequent subtype. Two URF recombination patterns were the same as CRF01_AE/B. HIV-1 genotype distribution showed a significant statistical difference in different demographic characteristics, such as source (P