Increased Concentrations of Interleukin-33 in the Serum and Cerebrospinal Fluid of Patients with Multiple Sclerosis

Objectives: Interleukin (IL)-33 is a cytokine with both pro- and anti-inflammatory effects involved in the pathogenesis of some inflammatory diseases. The purpose of this investigation was to evaluate the serum and cerebrospinal fluid (CSF) IL-33 concentrations in patients with multiple sclerosis (M...

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Bibliographic Details
Published in:Oman medical journal 2016, Vol.31 (1), p.40-45
Main Authors: Jamali , Mitra, Jafarzadeh , Abdollah, Nemati , Maryam, Hajghani , Hossain, Mahdavi , Roya, Ebrahimi , Hossain Ali
Format: Article
Language:English
Subjects:
BLOOD SERUM
Central nervous system
CEREBROSPINAL FLUID
Diseases
human
IL33 protein
INTERLEUKINS
MEDICAL SCIENCES
MULTIPLE SCLEROSIS
Original
PATIENTS
Serum
THERAPY
Treatment
الإنترلوكينات
التصلب المتعدد
السائل المخي النخاعي
العلاج
العلوم الطبية
المرضى
مصل الدم
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Summary:Objectives: Interleukin (IL)-33 is a cytokine with both pro- and anti-inflammatory effects involved in the pathogenesis of some inflammatory diseases. The purpose of this investigation was to evaluate the serum and cerebrospinal fluid (CSF) IL-33 concentrations in patients with multiple sclerosis (MS). Methods: Blood specimens were obtained from 140 patients with MS (46 males and 94 females) with various disease patterns and treatment plans and 140 healthy subjects (47 males and 93 females), who acted as a control group. CSF samples were collected from 20 MS group and 20 sex- and agematched patients with other neurological diseases of nonautoimmune etiology. The serum and CSF concentrations of IL-33 were measured by the enzyme-linked immunosorbent assay. Results: The serum and CSF IL-33 levels were significantly higher in the MS group compared to the control group (p
ISSN:1999-768X
2070-5204
DOI:10.5001/omj.2016.08