The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness

Human African trypanosomiasis due to Trypanosoma brucei rhodesiense is invariably fatal if untreated with up to 12.3 million people at a risk of developing the disease in Sub-Saharan Africa. The disease is characterized by a wide spectrum of clinical presentation coupled with differences in disease...

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Bibliographic Details
Published in:Allergy, asthma, and clinical immunology asthma, and clinical immunology, 2016-01, Vol.12 (3), p.4, Article 4
Main Authors: Kato, Charles D, Matovu, Enock, Mugasa, Claire M, Nanteza, Ann, Alibu, Vincent P
Format: Article
Language:English
Subjects:
Analysis
Cytokines
Epidemiology
Influence
Physiological aspects
Review
Trypanosoma brucei
Trypanosoma brucei rhodesiense
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Summary:Human African trypanosomiasis due to Trypanosoma brucei rhodesiense is invariably fatal if untreated with up to 12.3 million people at a risk of developing the disease in Sub-Saharan Africa. The disease is characterized by a wide spectrum of clinical presentation coupled with differences in disease progression and severity. While the factors determining this varied response have not been clearly characterized, inflammatory cytokines have been partially implicated as key players. In this review, we consolidate available literature on the role of specific cytokines in the pathogenesis of T. b. rhodesiense sleeping sickness and further discuss their potential as stage biomarkers. Such information would guide upcoming research on the immunology of sleeping sickness and further assist in the selection and evaluation of cytokines as disease stage or diagnostic biomarkers.
ISSN:1710-1484
1710-1492
1710-1492
DOI:10.1186/s13223-016-0113-5