Transient receptor potential channel C5 in cancer chemoresistance

The transient receptor potential （TRP） superfamily contains at least 28 homologs in mammalian. These proteins form TRP channels are permeable to monovalent and divalent cations and participate in a variety of physiological functions. Dysregulation of TRP channels is responsible for numerous diseases...

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Bibliographic Details
Published in:Acta pharmacologica Sinica 2016-01, Vol.37 (1), p.19-24
Main Authors: He, Dong-xu, Ma, Xin
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biomedical and Life Sciences
Biomedicine
Calcium - metabolism
Drug Resistance, Neoplasm
Homeostasis
Humans
Immunology
Internal Medicine
Medical Microbiology
Molecular Targeted Therapy
Mutation
Neoplasms - drug therapy
Neoplasms - metabolism
Pharmacology/Toxicology
Review
Signal Transduction
TRPC Cation Channels - genetics
TRPC Cation Channels - physiology
Vaccine
制剂
处方
药学
药理
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Summary:The transient receptor potential （TRP） superfamily contains at least 28 homologs in mammalian. These proteins form TRP channels are permeable to monovalent and divalent cations and participate in a variety of physiological functions. Dysregulation of TRP channels is responsible for numerous diseases. This review provides a brief short overview of mammalian TRP channels with a focus on TRPC5 and its role in cancers. Dysregulation of TRPC5 interrupts Oa2＋ homeostasis in cancer cells, which activates signaling pathways that are highly associated with cancer progression, especially cancer chemoresistance, Based on the important role of TRPCS, we also discuss the potential of TRPC5 as a target for therapeutic intervention, Either direct targeting of TRPC5 or indirect interruption of TRPC5-related signaling pathways may effectively overcome cancer chemoresistance.
ISSN:1671-4083
1745-7254
DOI:10.1038/aps.2015.109