Deciphering the effect of novel bacterial exopolysaccharide-based nanoparticle cream against Propionibacterium acnes

Acne vulgaris (acne) is a chronic inflammatory disease prevalent among adolescents and adults, with significant psychological effects. The aetiology of acne is multifactorial. Several pathophysiological associations have been identified in which Propionibacterium acnes plays a major role. This bacte...

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Bibliographic Details
Published in:3 Biotech 2016-12, Vol.6 (1), p.35-4, Article 35
Main Authors: Karlapudi, Abraham P., Kodali, Vidya P., Kota, Krishna P., Shaik, Sabiha S., Sampath Kumar, N. S., Dirisala, Vijaya R.
Format: Article
Language:English
Subjects:
Acne
Agriculture
Antimicrobial agents
Bacteria
Bioinformatics
Biomaterials
Biotechnology
Cancer Research
Chemistry
Chemistry and Materials Science
Fourier transforms
Nanoparticles
Propionibacterium acnes
Short Reports
Stem Cells
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Summary:Acne vulgaris (acne) is a chronic inflammatory disease prevalent among adolescents and adults, with significant psychological effects. The aetiology of acne is multifactorial. Several pathophysiological associations have been identified in which Propionibacterium acnes plays a major role. This bacteria primarily affects areas containing oil glands including the face, back and trunk, where it causes the formation of seborrhoea and inflammatory lesions. The treatment methods currently in place have side effects. A novel alternative method with no side effects is hence required. In this study, we report the synthesis of an exopolysaccharide (EPS)-producing bacterial-based nanoparticle as a stable biocompatible material for drug delivery. We then evaluated the effectiveness of EPS-based nanoparticle cream against P. acnes . Our results demonstrate that EPS nanoparticles have great potential as a safe and effective topical treatment for acne vulgaris and other associated infections.
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-015-0359-5