Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease

To validate novel single nucleotide polymorphisms (SNPs) in Greek patients with Crohn's disease (CD). A total of 120 patients with CD, 85 patients with UC, and 100 unrelated healthy controls were genotyped. Genotyping was performed by allele-specific PCR or by PCR-RFLP analysis. Our results sho...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2005-12, Vol.11 (47), p.7525-7530
Main Authors: Gazouli, Maria, Mantzaris, Gerassimos, Archimandritis, Athanassios J, Nasioulas, George, Anagnou, Nicholas P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Crohn Disease - epidemiology
Crohn Disease - genetics
Female
Genetic Predisposition to Disease
Greece
Humans
Male
Membrane Proteins - genetics
Middle Aged
Organic Cation Transport Proteins - genetics
Polymorphism, Single Nucleotide
Rapid Communication
Risk Factors
Solute Carrier Family 22 Member 5
Tumor Suppressor Proteins - genetics
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Description
Summary:To validate novel single nucleotide polymorphisms (SNPs) in Greek patients with Crohn's disease (CD). A total of 120 patients with CD, 85 patients with UC, and 100 unrelated healthy controls were genotyped. Genotyping was performed by allele-specific PCR or by PCR-RFLP analysis. Our results showed that the 1672T and -207C alleles were obviously over-represented in CD patients only (P
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i47.7525