Effects of naloxone on upper airway collapsibility in normal sleeping subjects

BACKGROUND: To evaluate the possible influence of endorphin release on upper airway collapsibility the effects of naloxone, an opiate receptor antagonist, were measured. METHODS: The effects of naloxone on upper airway collapsibility were studied in five normal sleeping men in a pilot study. During...

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Bibliographic Details
Published in:Thorax 1996-08, Vol.51 (8), p.851-852
Main Authors: Meurice, J. C., Marc, I., Sériès, F.
Format: Article
Language:English
Subjects:
Adult
beta-Endorphin - blood
Biological and medical sciences
Double-Blind Method
Humans
Investigative techniques of respiratory function
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Naloxone - pharmacology
Narcotic Antagonists - pharmacology
Pharyngeal Muscles - drug effects
Pharyngeal Muscles - physiology
Pilot Projects
Sleep - physiology
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Summary:BACKGROUND: To evaluate the possible influence of endorphin release on upper airway collapsibility the effects of naloxone, an opiate receptor antagonist, were measured. METHODS: The effects of naloxone on upper airway collapsibility were studied in five normal sleeping men in a pilot study. During a sleep fragmentation night the subjects received either naloxone or a volume matched saline placebo in a double blind crossover design. Critical pressure (Pcrit) was measured during a morning nap following sleep fragmentation. RESULTS: The plasma levels of endorphins increased during sleep fragmentation nights. Pcrit was significantly greater after placebo than after naloxone infusion. CONCLUSIONS: Naloxone may reduce upper airway collapsibility in normal sleeping subjects following sleep fragmentation.
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.51.8.851