Joint Effects of Intraocular Pressure and Myopia on Risk of Primary Open-Angle Glaucoma: The Singapore Epidemiology of Eye Diseases Study

• Published in: Scientific reports 2016-01, Vol.6 (1), p.19320-19320, Article 19320
• Main Authors: Tham, Yih-Chung, Aung, Tin, Fan, Qiao, Saw, Seang-Mei, Siantar, Rosalynn Grace, Wong, Tien Y., Cheng, Ching-Yu
• Format: Article
• Language: English
• Subjects: 692/499; 692/699/3161/3172; Aged; Cross-Sectional Studies; Epidemiology; Eye; Eye diseases; Female; Glaucoma; Glaucoma, Open-Angle - diagnosis; Glaucoma, Open-Angle - epidemiology; Glaucoma, Open-Angle - etiology; Humanities and Social Sciences; Humans; Intraocular Pressure; Male; Middle Aged; multidisciplinary; Myopia; Myopia - complications; Odds Ratio; Population Surveillance; Pressure; Regression analysis; Risk; Risk Factors; Science; Science (multidisciplinary); Singapore - epidemiology; Singapore - ethnology; Visual Fields
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep19320

We examined the joint effects of intraocular pressure (IOP) and myopia on the risk of primary open angle glaucoma (POAG) in a multi-ethnic Asian population. A total of 9,422 participants (18,469 eyes) in the Singapore Epidemiology of Eye Diseases Study were included. Of them, 213 subjects (273 eyes) had POAG. All participants underwent standardised examinations. The independent and joint effects of IOP and myopia on POAG were examined using logistic regression models. Generalised estimating equation models were used to account for correlation between eyes. Higher IOP, longer axial length and more negative spherical equivalent were independently associated with POAG, after adjusting for relevant covariates (all P ≤ 0.005). Significant interaction between IOP and myopia on POAG was observed ( P interaction = 0.025). Eyes with moderate-to-high myopia (−0.5 dioptres) and with IOP