Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-alpha treatment?

Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fasciolopsiasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, eve...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2005-12, Vol.11 (48), p.7688-7689
Main Authors: Sahin, Mehmet, Isler, Mehmet, Senol, Altug, Demirci, Mustafa, Aydin, Zeynep Dilek
Format: Article
Language:English
Subjects:
Acute Disease
Case Report
Fascioliasis - virology
Hepatitis C - complications
Hepatitis C - drug therapy
Hepatitis C - immunology
Humans
Interferon-alpha - therapeutic use
Male
Middle Aged
Th1 Cells - immunology
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Summary:Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fasciolopsiasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus (HCV) infection. We report here the case of a male patient who acquired Fasciola hepatica infection after an initial response to IFN-alpha therapy with a favorable outcome.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i48.7688