Sexually dimorphic effects of early life stress in rat pups on urinary bladder detrusor muscle contractility in adulthood

Painful bladder syndrome/interstitial cystitis (PBS/IC) is a chronic disorder that is commonly seen in women who report a history of adversity in early life. Here, we test the hypothesis that early life stress (ELS) induces sexually dimorphic abnormalities in urinary bladder smooth muscle function i...

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Bibliographic Details
Published in:Biology of sex differences 2016-01, Vol.7 (8), p.8-8, Article 8
Main Authors: Mohammadi, Ehsan, Prusator, Dawn K, Healing, Eleanor, Hurst, Robert, Towner, Rheal A, Wisniewski, Amy B, Greenwood-Van Meerveld, Beverley
Format: Article
Language:English
Subjects:
Care and treatment
Complications and side effects
Health aspects
Interstitial cystitis
Pain
Stress (Psychology)
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Summary:Painful bladder syndrome/interstitial cystitis (PBS/IC) is a chronic disorder that is commonly seen in women who report a history of adversity in early life. Here, we test the hypothesis that early life stress (ELS) induces sexually dimorphic abnormalities in urinary bladder smooth muscle function in adulthood. Male and female rat pups were conditioned on postnatal (PN) days 8-12 with either a "predictable or "unpredictable" odor-shock, or odor only control treatment. In adulthood, urinary bladder function was assessed in vivo via urine spot analysis and in vitro via contractile responses to electrical field stimulation (EFS) and membrane depolarization with potassium chloride (KCl). In adulthood, we found that female rats exposed to unpredictable ELS showed a significant (p 
ISSN:2042-6410
2042-6410
DOI:10.1186/s13293-016-0062-1