Erratum: Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus

Diabetes (DM) is prevalent in cirrhosis and may modulate the risk of hospitalization through gut dysbiosis. We aimed to define the role of gut microbiota on 90-day hospitalizations and of concomitant DM on microbiota. Cirrhotic outpatients with/without DM underwent stool and sigmoid mucosal microbia...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2016-01, Vol.6 (1), p.20447-20447, Article 20447
Main Authors: Bajaj, Jasmohan S., Betrapally, Naga S., Hylemon, Phillip B., Thacker, Leroy R., Daita, Kalyani, Kang, Dae Joong, White, Melanie B., Unser, Ariel B., Fagan, Andrew, Gavis, Edith A., Sikaroodi, Masoumeh, Dalmet, Swati, Heuman, Douglas M., Gillevet, Patrick M.
Format: Article
Language:English
Subjects:
692/308/53/2422
692/4020/4021/1607/1604
Erratum
Humanities and Social Sciences
multidisciplinary
Science
Science (multidisciplinary)
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diabetes (DM) is prevalent in cirrhosis and may modulate the risk of hospitalization through gut dysbiosis. We aimed to define the role of gut microbiota on 90-day hospitalizations and of concomitant DM on microbiota. Cirrhotic outpatients with/without DM underwent stool and sigmoid mucosal microbial analysis and were followed for 90 days. Microbial composition was compared between those with/without DM, and those who were hospitalized/not. Regression/ROC analyses for hospitalizations were performed using clinical and microbial features. 278 cirrhotics [39% hepatic encephalopathy (HE), 31%DM] underwent stool while 72 underwent mucosal analyses. Ultimately, 94 were hospitalized and they had higher MELD, proton pump inhibitor (PPI) use and HE without difference in DM. Stool/mucosal microbiota were significantly altered in those who were hospitalized (UNIFRAC p
ISSN:2045-2322
2045-2322
DOI:10.1038/srep20447