Proteomic Profiling of Serum-Derived Exosomes from Ethnically Diverse Prostate Cancer Patients

Prostate cancer (PCa) remains the most frequently diagnosed male malignancy in Western countries and the second most common cause of male cancer death in the United States. The relatively elevated PCa incidence and mortality among African American men makes this cancer type a challenging health disp...

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Bibliographic Details
Published in:Cancer investigation 2016-01, Vol.34 (1), p.1-11
Main Authors: Turay, David, Khan, Salma, Diaz Osterman, Carlos J., Curtis, Matthew P., Khaira, Balreet, Neidigh, Jonathan W., Mirshahidi, Saied, Casiano, Carlos A., Wall, Nathan R.
Format: Article
Language:English
Subjects:
Biomarker
Biomarkers, Tumor
Case-Control Studies
Computational Biology
Early detection
Ethnic Groups
Exosome
Exosomes - metabolism
Health disparity
Humans
Male
Prostate cancer
Prostatic Neoplasms - blood
Prostatic Neoplasms - metabolism
Proteome
Proteomics - methods
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Summary:Prostate cancer (PCa) remains the most frequently diagnosed male malignancy in Western countries and the second most common cause of male cancer death in the United States. The relatively elevated PCa incidence and mortality among African American men makes this cancer type a challenging health disparity disease. To increase the chance for successful trea tment, earlier detection and prediction of tumor aggress iveness will be important and need to be resolved. This study demonstrates that small membrane-bound vesicles shed from the tumor called exosomes contain ethnically and tumor-specific biomarkers, and could be exploited for their diagnostic and therapeutic potential.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2015.1081921