Immunomodulatory Effects of Chitotriosidase Enzyme

Chitotriosidase enzyme (EC: 3.2.1.14) is the major active chitinase in the human body. It is produced mainly by activated macrophages, in which its expression is regulated by multiple intrinsic and extrinsic signals. Chitotriosidase was confirmed as essential element in the innate immunity against c...

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Bibliographic Details
Published in:Enzyme Research 2016, Vol.2016, p.18-26
Main Authors: Elmonem, Mohamed A., van den Heuvel, Lambertus P., Levtchenko, Elena N.
Format: Article
Language:English
Subjects:
Cancer cells
Chronic obstructive pulmonary disease
Enzymes
Genes
Hydrolases
Immunity
Macrophages
Metabolic disorders
Mutation
Review
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Summary:Chitotriosidase enzyme (EC: 3.2.1.14) is the major active chitinase in the human body. It is produced mainly by activated macrophages, in which its expression is regulated by multiple intrinsic and extrinsic signals. Chitotriosidase was confirmed as essential element in the innate immunity against chitin containing organisms such as fungi and protozoa; however, its immunomodulatory effects extend far beyond innate immunity. In the current review, we will try to explore the expanding spectrum of immunological roles played by chitotriosidase enzyme in human health and disease and will discuss its up-to-date clinical value.
ISSN:2090-0414
2090-0406
2090-0414
DOI:10.1155/2016/2682680