Reprogramming the T Cell Response to Tuberculosis

Coscolla, Copin et al. recently used comparative genomics of M. tuberculosis (Mtb) strains to show that most human T cell-recognized epitopes are hyperconserved, but bona fide variable epitopes also exist. This identification of two sets of antigens implies opposing evolutionary processes and will h...

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Bibliographic Details
Published in:Trends in immunology 2016-02, Vol.37 (2), p.81-83
Main Authors: Woodworth, Joshua S, Andersen, Peter
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigens
Antigens, Bacterial - immunology
Epitopes
Genomes
Genomics
Humans
Immune system
Infections
Lymphocytes
Mycobacterium
Mycobacterium tuberculosis - immunology
T-Lymphocytes - immunology
Tuberculosis
Tuberculosis - immunology
Tuberculosis Vaccines - immunology
Vaccines
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Summary:Coscolla, Copin et al. recently used comparative genomics of M. tuberculosis (Mtb) strains to show that most human T cell-recognized epitopes are hyperconserved, but bona fide variable epitopes also exist. This identification of two sets of antigens implies opposing evolutionary processes and will have an important impact on tuberculosis (TB) vaccine strategy and design.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2015.12.009