Myocardial Regional Interstitial Fibrosis is Associated With Left Intra-Ventricular Dyssynchrony in Patients With Heart Failure: A Cardiovascular Magnetic Resonance Study

Left ventricular (LV) dyssynchrony is associated with poor prognosis in patients with heart failure (HF). The mechanisms leading to LV dyssynchrony are not fully elucidated. This study evaluates whether myocardium regional variation in interstitial fibrosis is associated with LV dyssynchrony. Forty-...

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Bibliographic Details
Published in:Scientific reports 2016-02, Vol.6 (1), p.20711-20711, Article 20711
Main Authors: Lin, Lian-Yu, Wu, Cho-Kai, Juang, Jyh-Ming Jimmy, Wang, Yi-Chih, Su, Mao-Yuan Marine, Lai, Ling-Ping, Hwang, Juey-Jen, Chiang, Fu-Tien, Tseng, Wen-Yih Issac, Lin, Jiunn-Lee
Format: Article
Language:English
Subjects:
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Aged
Beta blockers
Endomyocardial Fibrosis - complications
Female
Fibrosis
Heart diseases
Heart failure
Heart Failure - diagnostic imaging
Heart Failure - physiopathology
Heart Ventricles - physiopathology
Humanities and Social Sciences
Humans
Magnetic Resonance Imaging
Male
Middle Aged
multidisciplinary
Myocardium
NMR
Nuclear magnetic resonance
Prognosis
Science
Ventricle
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - etiology
Ventricular Function, Left
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Summary:Left ventricular (LV) dyssynchrony is associated with poor prognosis in patients with heart failure (HF). The mechanisms leading to LV dyssynchrony are not fully elucidated. This study evaluates whether myocardium regional variation in interstitial fibrosis is associated with LV dyssynchrony. Forty-two patients with systolic heart failure (SHF), 76 patients with heart failure with preserved ejection fraction (HFpEF) and 20 patients without HF received cardiovascular magnetic resonance imaging (MRI) study. LV was divided into 18 segments by short-axis view. In each segment, regional extracellular volume fraction (ECV) and the time taken to reach minimum regional volume (Tmv) were derived. Intra-LV dyssynchrony were represented by maximum difference (Dysyn_max) and standard deviation (Dysyn_sd) of all Tmv. The results showed that among the covariates, only age (1.87, 95% CI: 0.61–3.13, p = 0.004) and ECV (3.77, 95% CI: 2.72–4.81, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep20711