Osmostress‐induced gene expression – a model to understand how stress‐activated protein kinases (SAPKs) regulate transcription

Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden changes in the environment. Several aspects of cell physiology change during adaptation. Major changes in gene expression are associated with cell exposure to environmental changes, and several aspects of...

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Bibliographic Details
Published in:The FEBS journal 2015-09, Vol.282 (17), p.3275-3285
Main Authors: Nadal, Eulàlia, Posas, Francesc
Format: Article
Language:English
Subjects:
adaptation
Adaptation, Physiological - genetics
Animals
biogenesis
case studies
Cell Cycle - genetics
cell viability
cells
Chromatin Assembly and Disassembly
Cèl·lules
environmental exposure
Gene expression
Gene Expression Regulation, Fungal
gene induction
Hog1
Kinases
Mammals
messenger RNA
mitogen-activated protein kinase
Mitogen-Activated Protein Kinases - genetics
Mitogen-Activated Protein Kinases - metabolism
Osmostress
Osmotic Pressure
p38
Proteïnes quinases
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
SAPK
Signal Transduction
State‐of‐the‐Art Review
Stress responses
Stress, Physiological - genetics
Transcription, Genetic
Yeast
Yeasts
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Summary:Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden changes in the environment. Several aspects of cell physiology change during adaptation. Major changes in gene expression are associated with cell exposure to environmental changes, and several aspects of mRNA biogenesis appear to be targeted by signaling pathways upon stress. Exhaustive reviews have been written regarding adaptation to stress and regulation of gene expression. In this review, using osmostress in yeast as a prototypical case study, we highlight those aspects of regulation of gene induction that are general to various environmental stresses as well as mechanistic aspects that are potentially conserved from yeast to mammals.
ISSN:1742-464X
1742-4658
DOI:10.1111/febs.13323