Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection

The performance of an assay to detect antibodies to a norovirus nonstructural fusion protein, designated VPR and consisting of three proteins (GI.1 virus protein genome-linked [VPg], a virus protease, and an RNA-dependent RNA polymerase), was evaluated. The assay sensitivity and specificity were 74....

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Bibliographic Details
Published in:Clinical and vaccine immunology 2016-02, Vol.23 (2), p.181-183
Main Authors: Hesse, Shayla, Neill, Frederick H, Estes, Mary K, Shanker, Sreejesh, Prasad, B V Venkataram, Ferreira, Jennifer, Atmar, Robert L
Format: Article
Language:English
Subjects:
Administration, Intranasal
Antibodies, Viral - blood
Antibodies, Viral - immunology
Caliciviridae Infections - diagnosis
Caliciviridae Infections - immunology
Caliciviridae Infections - virology
Feces - virology
Humans
Immunoassay
Norovirus
Norovirus - chemistry
Norovirus - immunology
Sensitivity and Specificity
Vaccines
Vaccines, Virus-Like Particle - administration & dosage
Vaccines, Virus-Like Particle - immunology
Viral Fusion Proteins - immunology
Viral Nonstructural Proteins - immunology
Viral Vaccines - administration & dosage
Viral Vaccines - immunology
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Summary:The performance of an assay to detect antibodies to a norovirus nonstructural fusion protein, designated VPR and consisting of three proteins (GI.1 virus protein genome-linked [VPg], a virus protease, and an RNA-dependent RNA polymerase), was evaluated. The assay sensitivity and specificity were 74.5% and >95%, respectively, for identifying GI.1 norovirus infection among persons who received either a monovalent GI.1 norovirus virus-like particle (VLP) vaccine or placebo by the intranasal route followed by an oral live GI.1 norovirus challenge.
ISSN:1556-6811
1556-679X
DOI:10.1128/CVI.00595-15