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Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection

The performance of an assay to detect antibodies to a norovirus nonstructural fusion protein, designated VPR and consisting of three proteins (GI.1 virus protein genome-linked [VPg], a virus protease, and an RNA-dependent RNA polymerase), was evaluated. The assay sensitivity and specificity were 74....

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Published in:	Clinical and vaccine immunology 2016-02, Vol.23 (2), p.181-183
Main Authors:	Hesse, Shayla, Neill, Frederick H, Estes, Mary K, Shanker, Sreejesh, Prasad, B V Venkataram, Ferreira, Jennifer, Atmar, Robert L
Format:	Article
Language:	English
Subjects:	Administration, Intranasal Antibodies, Viral - blood Antibodies, Viral - immunology Caliciviridae Infections - diagnosis Caliciviridae Infections - immunology Caliciviridae Infections - virology Feces - virology Humans Immunoassay Norovirus Norovirus - chemistry Norovirus - immunology Sensitivity and Specificity Vaccines Vaccines, Virus-Like Particle - administration & dosage Vaccines, Virus-Like Particle - immunology Viral Fusion Proteins - immunology Viral Nonstructural Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology
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creator	Hesse, Shayla Neill, Frederick H Estes, Mary K Shanker, Sreejesh Prasad, B V Venkataram Ferreira, Jennifer Atmar, Robert L
description	The performance of an assay to detect antibodies to a norovirus nonstructural fusion protein, designated VPR and consisting of three proteins (GI.1 virus protein genome-linked [VPg], a virus protease, and an RNA-dependent RNA polymerase), was evaluated. The assay sensitivity and specificity were 74.5% and >95%, respectively, for identifying GI.1 norovirus infection among persons who received either a monovalent GI.1 norovirus virus-like particle (VLP) vaccine or placebo by the intranasal route followed by an oral live GI.1 norovirus challenge.
doi_str_mv	10.1128/CVI.00595-15
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source	American Society for Microbiology Journals; PubMed Central; Alma/SFX Local Collection
subjects	Administration, Intranasal Antibodies, Viral - blood Antibodies, Viral - immunology Caliciviridae Infections - diagnosis Caliciviridae Infections - immunology Caliciviridae Infections - virology Feces - virology Humans Immunoassay Norovirus Norovirus - chemistry Norovirus - immunology Sensitivity and Specificity Vaccines Vaccines, Virus-Like Particle - administration & dosage Vaccines, Virus-Like Particle - immunology Viral Fusion Proteins - immunology Viral Nonstructural Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology
title	Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection
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