Rapid 3D Extrusion of Synthetic Tumor Microenvironments

The spatial positioning of 3D tumor‐mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2015-10, Vol.27 (37), p.5512-5517
Main Authors: Grolman, Joshua M., Zhang, Douglas, Smith, Andrew M., Moore, Jeffrey S., Kilian, Kristopher A.
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - physiopathology
Alginates - chemical synthesis
Alginates - chemistry
Animals
Architecture
Biomimetic Materials - chemical synthesis
Biomimetic Materials - chemistry
Breast Neoplasms - drug therapy
Breast Neoplasms - physiopathology
Cell Line, Tumor
Cell Movement - drug effects
Cell Movement - physiology
Cell Survival - drug effects
Cell Survival - physiology
Coculture Techniques
Devices
Drugs
Equipment Design
Extrusion
Glucuronic Acid - chemical synthesis
Glucuronic Acid - chemistry
Hexuronic Acids - chemical synthesis
Hexuronic Acids - chemistry
Humans
Hydrogels - chemical synthesis
Hydrogels - chemistry
Lab-On-A-Chip Devices
Macrophages
Macrophages - drug effects
Macrophages - physiology
Mice
microfluidics
Microfluidics - instrumentation
Microfluidics - methods
Migration
patterned hydrogels
Three dimensional
tissue engineering
Tissue Scaffolds
Tumor Microenvironment - drug effects
Tumor Microenvironment - physiology
tumor microenvironments
Tumors
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Summary:The spatial positioning of 3D tumor‐mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201501729