PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer

The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial-mesenchymal transition. JunB levels were increased in GBC samples an...

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Bibliographic Details
Published in:Oncotarget 2015-10, Vol.6 (30), p.29076-29086
Main Authors: Lian, Shixian, Shao, Yebo, Liu, Houbao, He, Junyi, Lu, Weiqi, Zhang, Yong, Jiang, Ying, Zhu, Jun
Format: Article
Language:English
Subjects:
3-Phosphoinositide-Dependent Protein Kinases - genetics
3-Phosphoinositide-Dependent Protein Kinases - metabolism
Animals
Cell Line, Tumor
Cell Movement
Epithelial-Mesenchymal Transition
Female
Gallbladder Neoplasms - enzymology
Gallbladder Neoplasms - genetics
Gallbladder Neoplasms - mortality
Gallbladder Neoplasms - pathology
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Male
Mice, Nude
Middle Aged
Neoplasm Invasiveness
Prognosis
Research Paper
Signal Transduction
Time Factors
Transcription Factors - genetics
Transcription Factors - metabolism
Transfection
Up-Regulation
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Summary:The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial-mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.4931