Co-occurrence of biphenotypic acute leukaemia, glucose 6-phosphate dehydrogenase deficiency and haemoglobin E trait in a single child

Acute leukaemias occur as the result of clonal expansion subsequent to transformation and arrest at a normal differentiation stage of haematopoietic precursors, which commit to a single lineage, such as myeloid or B-lymphoid or T-lymphoid cells. Biphenotypic acute leukaemia (BAL) constitutes a biolo...

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Bibliographic Details
Published in:BMJ case reports 2016-02, Vol.2016, p.bcr2015212714
Main Authors: Mallick, Debkrishna, Thapa, Rajoo, Biswas, Biswajit
Format: Article
Language:English
Subjects:
Asia
Bone marrow
Child, Preschool
Classification
Dehydrogenases
Family medical history
Glucose
Glucosephosphate Dehydrogenase Deficiency - diagnosis
Glucosephosphate Dehydrogenase Deficiency - genetics
Glucosephosphate Dehydrogenase Deficiency - immunology
Hematology
Hemoglobin E - genetics
Hemoglobin E - immunology
Humans
Immunophenotyping
Indian Sub-Continent
Leukemia
Leukemia, Biphenotypic, Acute - diagnosis
Leukemia, Biphenotypic, Acute - genetics
Leukemia, Biphenotypic, Acute - immunology
Male
Parents - psychology
Precursor Cells, B-Lymphoid - immunology
Prognosis
T cell receptors
Treatment Refusal
Unusual Association of Diseases/Symptoms
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Summary:Acute leukaemias occur as the result of clonal expansion subsequent to transformation and arrest at a normal differentiation stage of haematopoietic precursors, which commit to a single lineage, such as myeloid or B-lymphoid or T-lymphoid cells. Biphenotypic acute leukaemia (BAL) constitutes a biologically different group of leukaemia arising from a precursor stem cell and co-expressing more than one lineage specific marker. The present report describes a child with unusual co-occurrence of biphenotypic (B-precursor cell and Myeloid) acute leukaemia, haemoglobin E trait and glucose 6-phosphate dehydrogenase (G6-PD) deficiency. To the best of our knowledge, this constellation of haematological conditions in a single child has never been described before.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2015-212714