Relation of Pre-anthracycline Serum Bilirubin Levels to Left Ventricular Ejection Fraction After Chemotherapy

Myocardial injury because of oxidative stress manifesting through reductions in left ventricular ejection fraction (LVEF) may occur after the administration of anthracycline-based chemotherapy (A-bC). We hypothesized that bilirubin, an effective endogenous antioxidant, may attenuate the reduction in...

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Bibliographic Details
Published in:The American journal of cardiology 2015-12, Vol.116 (11), p.1752-1755
Main Authors: Vera, Trinity, MD, D'Agostino, Ralph B., PhD, Jordan, Jennifer H., PhD, Whitlock, Matthew C., MD, Meléndez, Giselle C., MD, Lamar, Zanetta S., MD, Porosnicu, Mercedes, MD, Bonkovsky, Herbert L., MD, Poole, Leslie B., PhD, Hundley, W. Gregory, MD
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Anthracycline
Anthracyclines - adverse effects
Anthracyclines - pharmacology
Anthracyclines - therapeutic use
Antibiotics, Antineoplastic - pharmacology
Antibiotics, Antineoplastic - therapeutic use
Antineoplastic Agents - adverse effects
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Antioxidants
Bilirubin
Bilirubin - blood
Breast Neoplasms - blood
Breast Neoplasms - drug therapy
Cancer
Cancer therapies
Cardiovascular
Cardiovascular disease
Chemotherapy
Chi-square test
Congestive heart failure
Coronary artery disease
Coronary vessels
Daunorubicin - pharmacology
Daunorubicin - therapeutic use
Diabetes
Diabetes mellitus
Doxorubicin - pharmacology
Doxorubicin - therapeutic use
Enzymes
Female
Gender
Heart attacks
Heart diseases
Hematocrit
Hematologic Neoplasms - blood
Hematologic Neoplasms - drug therapy
Humans
Hypertension
Idarubicin - pharmacology
Idarubicin - therapeutic use
Injury prevention
Liver diseases
Male
Medical records
Middle Aged
Myocardial infarction
Oxidative Stress
Preservation
Retrospective Studies
Signs and symptoms
Stroke Volume - drug effects
Trends
Variance analysis
Ventricle
Ventricular Dysfunction, Left - chemically induced
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Summary:Myocardial injury because of oxidative stress manifesting through reductions in left ventricular ejection fraction (LVEF) may occur after the administration of anthracycline-based chemotherapy (A-bC). We hypothesized that bilirubin, an effective endogenous antioxidant, may attenuate the reduction in LVEF that sometimes occurs after receipt of A-bC. We identified 751 consecutively treated patients with cancer who underwent a pre-A-bC LVEF measurement, exhibited a serum total bilirubin level
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2015.08.042