ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases

Chronic musculoskeletal pain is debilitating and affects ∼ 20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2015-11, Vol.30 (6), p.449-459
Main Authors: Abdelhamid, Ramy E, Sluka, Kathleen A
Format: Article
Language:English
Subjects:
Acid Sensing Ion Channels - metabolism
Animals
Disease Models, Animal
Humans
Hydrogen-Ion Concentration
Muscle, Skeletal - innervation
Muscle, Skeletal - metabolism
Musculoskeletal Pain - metabolism
Musculoskeletal Pain - physiopathology
Myositis - metabolism
Myositis - physiopathology
Nociception
Pain Threshold
Reviews
Signal Transduction
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Summary:Chronic musculoskeletal pain is debilitating and affects ∼ 20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate nociception. This review discusses the properties of different types of ASICs, factors affecting their pH sensitivity, and their role in musculoskeletal hyperalgesia and inflammation.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00030.2015