Basic FGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons

Tendon injury during limb motion is common. Damaged tendons heal poorly and frequently undergo unpredictable ruptures or impaired motion due to insufficient innate healing capacity. By basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF) gene therapy via adeno-associate...

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Bibliographic Details
Published in:Scientific reports 2016-02, Vol.6 (1), p.20643-20643, Article 20643
Main Authors: Tang, Jin Bo, Wu, Ya Fang, Cao, Yi, Chen, Chuan Hao, Zhou, You Lang, Avanessian, Bella, Shimada, Masaru, Wang, Xiao Tian, Liu, Paul Y.
Format: Article
Language:English
Subjects:
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Animals
Cell Proliferation
Chickens
Collagen (type I)
Collagen Type I - agonists
Collagen Type I - genetics
Collagen Type I - metabolism
Dependovirus - genetics
Dependovirus - metabolism
Fibroblast growth factor 2
Fibroblast Growth Factor 2 - agonists
Fibroblast Growth Factor 2 - genetics
Fibroblast Growth Factor 2 - metabolism
Fibronectins - agonists
Fibronectins - genetics
Fibronectins - metabolism
Gene Expression Regulation
Gene therapy
Genetic Therapy - methods
Genetic Vectors - chemistry
Genetic Vectors - metabolism
Humanities and Social Sciences
Laminin - agonists
Laminin - genetics
Laminin - metabolism
multidisciplinary
Primary Cell Culture
Science
Tendon Injuries - genetics
Tendon Injuries - metabolism
Tendon Injuries - pathology
Tendon Injuries - therapy
Tendons
Tendons - metabolism
Tendons - pathology
Tenocytes - cytology
Tenocytes - metabolism
Tensile Strength
Transgenes
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - agonists
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor A - metabolism
Wound Healing - genetics
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Summary:Tendon injury during limb motion is common. Damaged tendons heal poorly and frequently undergo unpredictable ruptures or impaired motion due to insufficient innate healing capacity. By basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF) gene therapy via adeno-associated viral type-2 (AAV2) vector to produce supernormal amount of bFGF or VEGF intrinsically in the tendon, we effectively corrected the insufficiency of the tendon healing capacity. This therapeutic approach (1) resulted in substantial amelioration of the low growth factor activity with significant increases in bFGF or VEGF from weeks 4 to 6 in the treated tendons (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep20643