Plain to point network reduced graphene oxide - activated carbon composites decorated with platinum nanoparticles for urine glucose detection

• Published in: Scientific reports 2016-02, Vol.6 (1), p.21009-21009, Article 21009
• Main Authors: Hossain, Mohammad Faruk, Park, Jae Y.
• Format: Article
• Language: English
• Subjects: 140/146; 142/126; 631/45/603; 639/301/1005/1009; Activated carbon; Biosensing Techniques; Biosensors; Chemoreception; Chitosan; Electrodes; Glucose; Glucose - chemistry; Glucose - isolation & purification; Glucose oxidase; Glucose Oxidase - chemistry; Glycosuria - urine; Humanities and Social Sciences; Humans; Metal Nanoparticles - chemistry; multidisciplinary; Nanoparticles; Nanotubes, Carbon - chemistry; Platinum; Platinum - chemistry; Science; Science (multidisciplinary); Sensors; Urine
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep21009

In this study, a hydrothermal technique was applied to synthesize glucose-treated reduced graphene oxide-activated carbon (GRGO/AC) composites. Platinum nanoparticles (PtNP) were electrochemically deposited on the modified GRGO/AC surface, and chitosan-glucose oxidase (Chit-GOx) composites and nafion were integrated onto the modified surface of the working electrode to prepare a highly sensitive glucose sensor. The fabricated biosensor exhibited a good amperometric response to glucose in the detection range from 0.002 mM to 10 mM, with a sensitivity of 61.06 μA/mMcm 2 , a short response time (4 s) and a low detection limit of 2 μM (signal to noise ratio is 3). The glucose sensor exhibited a negligible response to interference and good stability. In addition, the glucose levels in human urine were tested in order to conduct a practical assessment of the proposed sensor, and the results indicate that the sensor had superior urine glucose recognition. These results thus demonstrate that the noble nano-structured electrode with a high surface area and electrocatalytic activity offers great promise for use in urine glucose sensing applications.