Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury

Graphical abstract Schematic representation showing that the ATP, ADP and UDP released following neuronal injury directly/indirectly act on microglial P2Y12 receptor, a G-protein-coupled receptor linked to a potassium channel, eliciting an outward potassium current. Inhibitors of G-proteins blocked...

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Bibliographic Details
Published in:Neuroscience 2016-03, Vol.318, p.22-33
Main Authors: Swiatkowski, P, Murugan, M, Eyo, U.B, Wang, Y, Rangaraju, S, Oh, S.B, Wu, L.-J
Format: Article
Language:English
Subjects:
Animals
Astrocytes - metabolism
ATP
Central Nervous System - injuries
Central Nervous System - metabolism
Female
K+ channels
Male
Membrane Potentials - physiology
Mice, Inbred C57BL
microglia
Microglia - metabolism
Neurology
Neurons - metabolism
P2Y12 receptor
Potassium - metabolism
Potassium Channels - metabolism
Receptors, Purinergic P2Y12 - metabolism
Signal Transduction - physiology
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Summary:Graphical abstract Schematic representation showing that the ATP, ADP and UDP released following neuronal injury directly/indirectly act on microglial P2Y12 receptor, a G-protein-coupled receptor linked to a potassium channel, eliciting an outward potassium current. Inhibitors of G-proteins blocked the P2Y12 receptor-mediated outward potassium current. Moreover, this outward current was found to be sensitive to certain potassium channel blockers such as quinine and bupivacaine, while being insensitive to TEA and 4-AP. Arrow-headed lines and bar-headed lines to indicate activation and inhibition, respectively. Dotted lines represent hypothetical associations.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.01.008