Collision tumour of large-cell neuroendocrine carcinoma and adenocarcinoma in the stomach: A case report

Concurrence of adenocarcinoma and large-cell neuroendocrine carcinoma of the stomach is a rare condition. Here, we report a case of gastric collision tumour with large-cell neuroendocrine carcinoma and adenocarcinoma. A 71-year-old Peruvian man presented with nausea, epigastric pain, and weight loss...

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Bibliographic Details
Published in:Ecancermedicalscience 2016-01, Vol.10, p.616
Main Authors: Payet, Eduardo, Pilco, Pau I, Montes, Jaime, Cordero-Morales, Alejandra, Savitzky, Maria Jose, Stenning-Persivale, Karoline
Format: Article
Language:English
Subjects:
Case Report
Case reports
Lymphatic system
Metastasis
Stomach
Surgery
Tumors
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Summary:Concurrence of adenocarcinoma and large-cell neuroendocrine carcinoma of the stomach is a rare condition. Here, we report a case of gastric collision tumour with large-cell neuroendocrine carcinoma and adenocarcinoma. A 71-year-old Peruvian man presented with nausea, epigastric pain, and weight loss for seven months. An Endoscopic evaluation revealed a huge ulcerative and infiltrative mass in the upper and middle third of the stomach. The patient underwent a D2 total gastrectomy. Microscopically, two separated and attached ulcerative lesions were recognised. The proximal to the cardial lesion showed neuroendocrine morphology and immunoreactivity for synaptophysin, and the other a moderated tubular adenocarcinoma Borrmann type III. Both lesions invaded serosa and lymph nodes metastases were found in 17 of 41 lymph nodes retrieved (one lymph node with neuroendocrine metastatic deposits).
ISSN:1754-6605
1754-6605
DOI:10.3332/ecancer.2016.616