Cytochemical profile of B and T leukaemic lymphocytes with special reference to acute lymphoblastic leukaemia

The PAS and acid phosphatase reactions showed a different pattern of positivity in the cells of lymphoproliferative disorders according to their B or T cell nature. In B-cell leukaemias (chronic lymphocytic and prolymphocytic) a low proportion of lymphocytes gave a positive result with the acid phos...

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Bibliographic Details
Published in:Journal of clinical pathology 1974-10, Vol.27 (10), p.767-771
Main Authors: Catovsky, D., Galetto, J., Okos, A., Miliani, E., Galton, D. A. G.
Format: Article
Language:English
Subjects:
Acid Phosphatase - metabolism
Adolescent
Adult
B-Lymphocytes - classification
B-Lymphocytes - metabolism
Cell Count
Cell Membrane - immunology
Child
Child, Preschool
Female
Histocytochemistry
Humans
Leukemia, Lymphoid - diagnosis
Leukemia, Lymphoid - immunology
Leukemia, Lymphoid - pathology
Male
T-Lymphocytes - classification
T-Lymphocytes - metabolism
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Summary:The PAS and acid phosphatase reactions showed a different pattern of positivity in the cells of lymphoproliferative disorders according to their B or T cell nature. In B-cell leukaemias (chronic lymphocytic and prolymphocytic) a low proportion of lymphocytes gave a positive result with the acid phosphatase reaction, while the majority were PAS positive in granular form. In contrast, in the T-prolymphocytic and T-lymphoblastic leukaemias the acid phosphatase reaction was positive in the majority of cells, while the PAS reaction was only positive in a minority. The significance of these findings, particularly for the recognition of a distinct T-cell variant of acute lymphoblastic leukaemia, is discussed.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.27.10.767